B. RESEARCH INTEREST AND SKILLS:
Applied quantum chemistry, theoretical bioinorganic chemistry and electrochemistry, metalloenzymatic and inorganic catalysis, C-H bond activation, good knowledge of quantum chemical programs (TURBOMOLE, Gaussian, Molpro, MOLCAS, ORCA, NWChem), QM/MM approaches, experience with bioinorganic spectroscopy (and analysis of spectroscopic data).
C. EDUCATION:
2005-2010
PhD degree Department of Modeling of Properties of Bio- and Nanostructures
at the Faculty of Science, Charles University, Prague.
Dissertation thesis: "Catalytic and Electronic Properties of Redox-Active and
Transition-Metal Complexes: Insights from Computational Chemistry",
supervised by Dr. L. Rulíšek (Institute of Organic Chemistry and Biochemistry (IOCB) AS CR, Prague).
2000-2005
MSc. degree Department of Physical and Macromolecular Chemistry, Faculty
of Science, Charles University, Prague
Diploma thesis: "IIa-VIa Diatomics and Their Oligomers: Theoretical Study"
supervised by Prof. Rudolf Zahradník (Institute of Physical Chemistry (JH-IPC) AS CR, Prague)
D. LIST OF PROFESSIONAL ACTIVITIES:
Employment:
since 2019
head of the Department of Computational Chemistry JH-IPC, AC CR
2013-present
researcher at JH-IPC, AS CR
2005-present
researcher at IOCB, AS CR (from 2013: 12% part-time job)
2002-2005
technical assistant at IPCH, AS CR
Research experience:
2019
stay in group of Prof. Ryan G. Hadt (Caltech, USA)
2011-2013
postdoctoral stay in the group of Prof. E. I. Solomon (Stanford University, USA);
both experimental and theoretical experiences in bioinorganic spectroscopy and reactivity
2011, 2012
beam time in Argonne National Laboratory, Chicago, USA
2010
stay in the group of Prof. E. I. Solomon (Stanford University, USA)
2008
stay in the group of Prof. U. Ryde (Lund University, Sweden)
2008
stay in the group of Prof. E. I. Solomon (Stanford University, USA)
2007
European Summerschool in Quantum Chemistry (Sicily)
2004
stay in the group of Prof. J.-M. Lehn (Strasbourg, France)
2004
School in Spectroscopic Methods and Their Applications (JH-IPC, Prague)
Selected Lectures and Invited Lectures
2019
Quantum Bioinorganic Chemistry (QBIC-V), Marseille, France (Invited)
2019
Student seminar, Caltech, USA (Invited)
2018
Quantum Bioinorganic Chemistry (QBIC-IV), Bath, UK
2018
7th Japan-CzechoSlovak Symposium of Theoretical Chemistry, Prague, CZ
2017
ACS Meeting, Washington DC, USA (Invited)
2017
ECOSTBio conference, Lisbon Portugal (Invited)
2016
ACS Meeting, San Diego USA (Invited)
2014
Central European Symposium on Theoretical Chemistry, Nagyborzsony Hungary (Invited)
2013
5th Japan-CzechoSlovak Symposium of Theoretical Chemistry, Nara Japan (Invited)
2009
3rd Japan-Czech-Slovak Symposium on Theoretical Chemistry, Bratislava (Invited)
Conference/seminar organization & guest editing:
2018
Collaborations bridging Physics, Chemistry, and Biology: Dreams and Reality (A joint
seminar between IOCB and JH-IPC); co-organized with Prof. P. Španěl.
2018
Guest editor of a special issue of Chemické listy prepared in the occasion of 90th
birthday of Prof. Rudolf Zahradník.
E. TEACHING:
Since 2019:
A member of master/PhD study board for the program Modeling of chemical properties of nano- and biostructures at Faculty of Science, Charles University.
2019:
Lecturer in School on molecular computational biochemistry, Krakow, Poland.
2015-present
Faculty of Science, Charles University: Master/PhD course on Computational
modeling of chemical reactions and enzymatic catalysis (in English.
2016-present
Bachelor course at Charles University “Chemical Structure B” on quantum
chemistry and molecular spectroscopy (in Czech).
F. AWARDS:
2009
Scopus Award 2009
2010
Participant of the Lindau Nobel Laureate Meeting 2010
2014-2018
The J. E. Purkyně Fellowship provided by the Academy of Science CR
2015
O. Wichterle Premium
G. GRANTS:
2015-2017
Junior project supported by Czech Grant Agency:
Redox Properties and Reactivities of Nonheme Iron Active Sites.
2018-2020
Senior project supported by Czech Grant Agency: Radical catalysis of enzymatic
and biomimetic polynuclear transition-metal active sites.
H. PUBLICATIONS:
40 peer-reviewed publications in international journals with more than 607 citations (Scopus; excluding self-citations: 529). H-index 14 (Scopus).
13 representative publications:
Bím D., Srnec M.* et al: Proc. Natl. Acad. Sci. U.S.A. 2018, 115, E10287-E10294. Srnec M.*, Roithová J. et al: Angew. Chem. Int. Ed. 2018, 57, 17053-17057.
Andris E., Srnec M.*, Roithová J. et al.: J. Am. Chem. Soc. 2017, 139, 2757-2765. Srnec M.*, Solomon, E. I.: J. Am. Chem. Soc. 2017, 139, 2396-2407. Srnec M., Wong S. D., Solomon E. I. et al.: J. Am. Chem. Soc. 2016, 138, 5110-5122.
Rokob T. A., Srnec M.*, Rulíšek et al.: J. Biol, Inorg. Chem. 2016, 21, 619-644.
Bím D., Rulíšek L., Srnec M.*: J. Phys. Chem. Lett. 2016, 7, 7-13.
Chalupský J., Rokob T. A., Rulíšek L., Srnec M.* et al.: J. Am. Chem. Soc. 2014, 136, 15977-15991.
Wong S. D., Srnec M., Solomon E. I. et al.: Nature 2013, 499, 320. shared first co-authorship.
Solomon E. I., Liu V. L., Light K. M., Srnec, M., Wong, S. D. Acc. Chem. Res. 2013, 46, 2725. Srnec M., Wong S. D., Solomon, E. I. et al.: Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 14326. Srnec M., Rokob T.A., Rulíšek L., Solomon, E. I. et al.: Inorg. Chem. 2012, 51, 2806. Srnec M., Chalupský J., Kývala M., Rulíšek L. J. Am. Chem. Soc. 2008, 130, 10947-10954.
